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KMID : 1134820090380091167
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Journal of the Korean Society of Food Science and Nutrition
2009 Volume.38 No. 9 p.1167 ~ p.1173
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An Extrapolation Concentration Decision Effect Antihyperlipidemic of Aglycone Isoflavone from Biotransformation Soybean on the Fed High-Fat Diet Rats
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Lim Ae-Kyoung
Jung Mee-Jung
Kim Dong-Woo
Hong Joo-Heon
Jung Hee-Kyoung
Kim Kil-Soo
Kim Yong-Hae
Kim Dae-Ik
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Abstract
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An extrapolation of bioflavone through biotransformation used Phellinus banmill KCTC16882 applied to 6 different rats group were carried out. Male Sprague-Dawley rats were fed with bioflavone free (normal: NO) diet, high-fat diet (control: CO) and diets containing 0.35%, 0.7% and 3.0% isoflavone for 8 week. Hyperlipidemia was induced by adding lard 200 g and cholesterol 10 g to CO and 0.35, 0.7 and 3.0% bioflavone diet. Bioflavone diet arrested increases in body weight without affecting feed intake in the rats. BFP-3.0 treated group showed signigicant reduction in the serum level of TG, TC and LDL-cholesterol (p＜0.05) compared to the CO, while HDL-cholesterol was increased (p＜0.05). The atherogenic index, ALT and AST were decreased in the BFP treated groups (p＜0.05). These results suggest that consumption of BFP may lead to extrapolation of an ameliortaion of metabolic syndromes as well as a reduction of cardiovascular disease and hyperlipidemia through increasing the of HDL-cholesterol, and decreasing the level of TG in serum.
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KEYWORD
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extrapolation, bioflavone, biotransformation, hyperlipidemia, cholesterol
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